For an oocyte to get Completely ready for fertilization and progress into an embryo, the right list of genes really should be turned on. Namekawa suspected that this pre-programming on the oocyte genome takes place in numerous stages — the main one starting off around the time a feminine is born. He believed that chromatin remodeling proteins did much of this work, by shifting spools about.
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This enables the oocytes to pause their progress and enter a holding sample, which lasts in the mouse’s adulthood. In mice missing PRC1, the oocytes didn’t pause their advancement; rather, they withered and died inside a month, leaving the mice forever infertile.
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At this time, the cell’s DNA is packaged that has a matrix of specialized proteins – leaving it primed to the vital second, decades afterwards, in the event the egg is fertilized and commences rising into an embryo.
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